Synthacaine produces a stimulating feeling with a hint of euphoria. An 80 mg dosage taken orally is enough to exhibit mild effects such as mood lift in under 30 minutes. Short term memory loss or forgetfulness is also common. Cognitive effects of synthacaine include mindfulness, alertness and a sympathetic feeling. Some users have likened its effects to MDMA and amphetamines. However, the euphoric effects are not overpowering, which makes synthacaine a relatively “safer” substance to use. Just like any other research chemicals, it is recommended to start with the lowest possible dosage.